REWRITING LIFE

Links

Genome Institute of Singapore.
60 Biopolis Street, Singapore, Singapore 138672.

chewwl@gis.a-star.edu.sg
Institute Profile | CHEW Wei Leong
Vector Core @ GIS

News

Addgene podcast post - 6 Feb 2018
Channel NewsAsia - Why It Matters S4 - Should We Hack Our Genes?
President's Science and Technology Awards - Young Scientist Award 2020 video
President's Science and Technology Awards - Young Scientist Award 2020 - The Straits Times
CNA Channel NewsAsia Interview video - 18 Dec 2020
C-to-G Base Editor Press Release - 4 Mar 2021
PRECISE - Rewriting the Human Genome
A Fulfilling Career in Applied Research with A*STAR
Gene editing cuts to the chase

Tweets by ChewWeiLeong

We are supported by:

Publications

Google Scholar
Pubmed

Choong Tat Keng,Thinesshwary Yogarajah,Regina Ching Hua Lee,Irfan Bin Hajis Muhammad,Bing Shao Chia,Suraj Rajan Vasandani,Daryl Shern Lim,Ke Guo,Yi Hao Wong,Chee Keng Mok,Justin Jang Hann Chu, Wei Leong Chew AAV-CRISPR-Cas13 eliminates human enterovirus and prevents death of infected mice. eBioMedicine (2023).
Choong Tat Keng, Ke Guo, Yu-Chi Liu, Kimberle Yanyin Shen, Daryl Shern Lim, Matthew Lovatt, Heng Pei Ang, Jodhbir S Mehta, Wei Leong Chew Multiplex viral tropism assay in complex cell populations with single-cell resolution. Gene Therapy (2022).
M. B. H. Irfan, L. W. Chen, N. T. X. Ong, and W. L. Chew. Primers. WO/2022/066104.
M. B. H. Irfan,W. L. Chew, and J. E. Park. Guide RNAs Targeting SARS-CoV-2. WO/2022/071890.
Chai RJ, Werner H, Li PY, Lee YL, Nyein KT, Solovei I, Luu TDA, Sharma B, Navasankari R, Maric M, Sim LYE, Loh YJ, Aliwarga E, Cheong JWL, Chojnowski A, Autio MI, Haiyang Y, Boon Tan KK, Keng CT, Ng SL, W. L. Chew, Ferenczi M, Burke B, Foo RSY, Stewart CL. Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy. Nature Communications (2021).
Lee, C. Q. E., B. Kerouanton, S. Chothani, S. Zhang, Y. Chen, C. K. Mantri, D. H. Hock, R. Lim, R. Nadkarni, V. T. Huynh, D. Lim, W. L. Chew, F. L. Zhong, D. A. Stroud, S. Schafer, V. Tergaonkar, A. L. St John, O. J. L. Rackham and L. Ho. Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Nature Communications (2021).
C. T. Keng and W. L. Chew. A Method For Assessing Transduction Efficiency And/Or Specificity Of Vectors At Single Cell Level. WO/2021/251905.
L. Chen, J. E. Park, P. Paa, P. D. Rajakumar, H.T. Prekop, Y. T. Chew, S. N. Manivannan, W. L. Chew. Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins. Nature Communications (2021). bioRxiv 213827.
C. T. Keng, J. H. Chu, W. L. Chew, and C. H. Lee. Molecular Systems And Therapies Using The Same. WO/2021/188058.
L. W. Chen and W. L. Chew. Nucleobase Editors. WO/2021/133261.
N. T. X. Ong, and W. L. Chew. Assays For Measuring Nucleic Acid Modifying Enzyme Activity. WO/2021/076053.
L. S. Tay, N. Palmer, R. Panwala, W. L. Chew, P. Mali. Translating CRISPR-Cas Therapeutics: Approaches and Challenges. The CRISPR Journal (2020).
A. M. Moreno, N. Palmer, F. Aleman, G. Chen, A. Pla, N. Jiang, W. L. Chew, M. Law, P. Mali. Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy. Nature biomedical engineering (2019). bioRxiv 245985.
G. M. Church and W. L. Chew. AAV split Cas9 genome editing and transcriptional regulation. PCT/US2017/032362, WO/2017/197238.
W. L. Chew. Immunity to CRISPR Cas9 and Cas12a therapeutics. Wiley Interdisciplinary Reviews Systems Biology and Medicine 10.1002/wsbm.1408. (2017)
L. Yang, A. Briggs, W. L. Chew, P. Mali, M. Guell, J. Aach, D. Goodman, D. Cox, Y. Kan, E. Lesha, V. Soundararajan, F. Zhang, G. M. Church. Engineering and optimising deaminase fusions for genome editing. Nature communications 7, 13330 (2016); published online Epub 2016 Nov 02 (10.1038/ncomms13330). bioRxiv 066597.
L. Zangi, M. S. Oliveira, L. Y. Ye, Q. Ma, N. Sultana, Y. Hadas, E. Chepurko, D. Später, B. Zhou, W. L. Chew, W. Ebina, M. Abrial, Q. D. Wang, W. T. Pu, and K. R. Chien. An IGF1R-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation 135, 59-72 (2017); published online Epub 2016 Nov 01 (10.1161/CIRCULATIONAHA.116.022064).
W. L. Chew, M. Tabebordbar, J. K. Cheng, P. Mali, E. Y. Wu, A. H. Ng, K. Zhu, A. J. Wagers, G. M. Church. A multifunctional AAV-CRISPR-Cas9 and its host response. Nature methods 13, 868-874 (2016); published online Epub 2016 Sep 05 (10.1038/nmeth.3993).
G. M. Church and W. L. Chew. Split Cas9 proteins. PCT/US2016/012570, WO/2016/112242.
A. J. Wagers, M. Tabebordbar, W. L. Chew, and G. M. Church. RNA-guided systems for in vivo gene editing. PCT/US2015/063181, WO/2016/089866.
W.L. Chew. Postnatal Genome Editing With CRISPR. (2016).
M. Tabebordbar, K. Zhu, J. K. Cheng, W. L. Chew, J. J. Widrick, W. X. Yan, C. Maesner, E. Y. Wu, R. Xiao, F. A. Ran, L. Cong, F. Zhang, L. H. Vandenberghe, G. M. Church, A. J. Wagers. In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science 351, 407-411 (2016); published online Epub 2015 Dec 31 (10.1126/science.aad5177).
J. Li, P. Kanju, M. Patterson, W. L. Chew, S. H. Cho, I. Gilmour, T. Oliver, R. Yasuda, A. Ghio, S. A. Simon, W. Liedtke. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environmental health perspectives 119, 784-793 (2011); published online Epub 2011 Jan 18 (10.1289/ehp.1002807).

WO/2016/089866 RNA-GUIDED SYSTEMS FOR IN VIVO GENE EDITING
WO/2016/112242 SPLIT CAS9 PROTEINS
WO2017197238 AAV SPLIT CAS9 GENOME EDITING AND TRANSCRIPTIONAL REGULATION
WO/2021/076053 ASSAYS FOR MEASURING NUCLEIC ACID MODIFYING ENZYME ACTIVITY
WO/2021/188058 MOLECULAR SYSTEMS AND THERAPIES USING THE SAME
WO/2021/133261 NUCLEOBASE EDITORS
WO/2021/251905 A METHOD FOR ASSESSING TRANSDUCTION EFFICIENCY AND/OR SPECIFICITY OF VECTORS AT SINGLE CELL LEVEL
WO/2022/066104 PRIMERS
GIS/Z/12079 CRISPR-Cas13...
GIS/Z/12092 CRISPR-Cas13...
GIS/Z/12126 ...LAMP...
GIS/Z/12363 ...AAV...
GIS/Z/12364 ...AAV...
GIS/Z/12568 ...vector design...
DxD/Z/12603 ...clinical...
GIS/Z/12602 ...isothermal...
GIS/Z/12783 ...Antiviral...
GIS/Z/13167 ...CGBE...
GIS/Z/13212 ...immunogencity...
GIS/Z/13214 ...immune...
GIS/Z/13241 ...C to G...
GIS/Z/13248 ...AAV...
GIS/Z/13449 ...AAV...
GIS/Z/13523 ...neutralisation...
GIS/Z/13739 ...AAV...
GIS/Z/13821 ...unnatural bases...

Research

Our team builds technologies for a world without diseases. We build technologies so that we can engineer DNA, make pinpoint changes to genes with CRISPR, deliver treatments with adeno-associated viruses (AAVs), make safer therapeutics that bypass adverse immune reactions, fight diseases, and save lives. Our overarching motivation is to establish safe and efficacious genome therapeutics for routine human use.

This is how we create new medicines. This is how we engineer life.

Team

Wei Leong CHEW | Principal Investigator
Ph.D. | Harvard University
B.S. | Duke University
Email

GUO Ke
GUO Ke | Assistant Lab Manager
Ph.D. | University of Berne
B.S. | Henan Medical University
Email

Eddie KENG Choong Tat | Research Associate
Ph.D. | National University of Singapore
M.Sc. | Nanyang Technological University, Singapore
B.S. | National University of Singapore
Email

Hong-Ting PREKOP | Programme Manager
Ph.D. | King’s College London
MRes | Imperial College London
B.A. | University of Cambridge
Email

Daryl LIM | Research Officer
B.S. | National University of Singapore
Email

CHEN Liwei | Research Officer
M.Sc. | Harvard University
B.S. | University of Chicago
Email

Amine MELIANI | Postdoctoral Fellow
PhD | Sorbonne University; Genethon
Masters | Paris Descartes University; AgroParisTech
BSc | University of Algiers
Email

CHIA Bing Shao | Research Fellow (NSS BS-PhD)
PhD | Harvard University
MS | Johns Hopkins University
BS | Johns Hopkins University
Email

Kimberle SHEN | Research Fellow (NSS BS-PhD)
PhD | Stanford University
BA | University of Cambridge
Email

Corina MOTOFEANU | Graduate Student (SINGA)
BSc | University of Manchester
Email

Samantha SEAH | Research Fellow (NSS BS-PhD)
PhD | EMBL Heidelberg
BA | University of Cambridge
Email

WANG Bolun | Postdoctoral Fellow
PhD | Peking University
BEng | Xi’an Jiaotong University
Email

Sharmada TOTAPALLY | Attachment Student
BEng | National University of Singapore

Alumni

Joshua JAMES | Graduate Student (ARAP - University of Manchester)
MSci | University of Bristol

Diya SRIVASTAVA | Research Officer
BSc | University of Sydney

Reyner JUSUF | Attachment Student
BSc | University College London

Drishtant CHAKRABORTY | Attachment Student
BSc | University of Cambridge

Nicholas ONG | Senior Research Fellow (NSS BS-PhD)
Ph.D. | Rice University
B.S. | Duke University

Benjamin WEBB | Senior Research Fellow
PhD | Imperial College London

KOH Zhi Kai | Attachment Student
BSc | Nanyang Technological University

Charmaine TAN Zi Yun | Attachment Student
BSc | University of California Los Angeles

Linette LUM Hui Min | Attachment Student
BSc | King’s College London

Mika THAM Ni Ya | Attachment Student
BSc | University College London

YANG Qize | Attachment Student (NSS BS 8-week)
BSc | Cambridge University

Lavina Sierra TAY | Programme Manager
Assistant Head | National Research Foundation, Singapore
PhD | National University of Singapore
BSc | University of Western Australia

June PARK Jung Eun | Postdoctoral Fellow
PhD | Seoul National University
BSc | Seoul Women’s University

Lekha RAVICHANDRAPRABHU | Research Officer
B.Eng. | Nanyang Technological University

MUHAMMAD Irfan Bin Hajis | Research Officer
B.Sc. | Nanyang Technological University

CHOI Yook Wah | Research Officer
B.Sc. | University of Nevada, Reno

Derek CHAN | Research Officer
B.Sc. | University of Queensland

Izavel LEE | Student Intern (NSS 8-week)
B.A. | University of Cambridge

Anna TRACZYK | Postdoctoral Fellow
Ph.D. | Nanyang Technological University
Master’s | Warsaw University of Technology
B.S. | Warsaw University of Technology

Priscilla RAJAKUMAR | Postdoctoral Fellow
PhD | University College London
Masters | University of Malaya
Bachelor | Kolej Universiti Sains dan Teknologi Malaysia

GOH Chen Gang | Research Officer (NSS)
B.Sc. | Imperial College London

Amanda LOH | RAOS Awardee; Student
Current student at University College London

Hannah NICHOLAS | Programme Manager, Apr 2019 - Mar 2020
Senior Lecturer in Molecular Biology (Tenured research and teaching) | University of Sydney
DPhil | University of Oxford
BMedSci | University of Sydney

Peter Jim PAA | Graduate Student (SINGA)
B.S. (First Class) | University of Manitoba
B.S. | University of the Philippines

Swathi Nachiar MANIVANNAN | Student Intern (NSS 8-week), Jul 2019 - Aug 2019
B.A. | University of Cambridge

HWANG Xueyan | Student Intern, Jul 2019 - Aug 2019
B.A. | University of Cambridge

CHEW Yi Ting | Student Intern (NSS 8-week), Jun 2019 - Aug 2019
B.A. | University of Cambridge

Sabranth GUPTA | Student Intern, Feb 2019 - Aug 2019
B.Tech. | Vellore Institute of Technology

Jerry TAN Wei Heng | Student Intern, Feb 2019 - Jul 2019
Commencing undergraduate studies

LEE Swee Leng | Student Intern, Feb 2019 - Jul 2019
Commencing undergraduate studies

CHOK Kian Chung | Student Intern, Dec 2018 - Mar 2019
B.S. | International Medical University

Suraj VASANDANI | Student Intern, Jun 2018 - Jun 2019
B.S. | Atma Jaya Catholic University

Franciscus Asisi ATMADI | Student Intern, May 2018 - Aug 2018
B.S. | National University of Singapore

KIM Sung Hwan | SIPGA Student, Dec 2017 - Feb 2018
M.Sc. | Seoul National University
B.S. | Hanyang University

Bagus SARMITO | Student Intern, Jun 2017 - Jun 2018
B.S. | Atma Jaya Catholic University

GOH Si Wei | Research Officer, Jun 2017 - Jun 2019
B.S. | National University of Singapore

* We are recruiting talented postdocs and research officers.
We mentor students through A*STAR scholarships and inter-institutional collaborations.
Email and come chat!

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chewlab.github.io

The Chew Lab at Genome Institute of Singapore.

We build technologies to rewrite the human genome

Our research broadly covers synthetic biology and technology development, with focus on genome-editing, CRISPR-Cas9, AAV, immunology, and gene therapy. To invent genome engineering technologies, we capitalize on nucleic acid manipulation, protein engineering, directed evolution, and high-throughput methodologies. Our overarching motivation is to establish safe and efficacious genome therapeutics for routine human use.

Wei Leong Chew